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Trp53tm1Mlh
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1Mlh
Name: transformation related protein 53; targeted mutation 1, Martin L Hooper
MGI ID: MGI:1857989
Synonyms: p53-
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60008
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of exons 2-6 with a neomycin cassette. (J:60008)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  155 strains or lines available
References
Original:  J:60008 Clarke AR, et al., Thymocyte apoptosis induced by p53-dependent and independent pathways [see comments]. Nature. 1993 Apr 29;362(6423):849-52
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory