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Grm1tm1Crpl
Targeted Allele Detail
Summary
Symbol: Grm1tm1Crpl
Name: glutamate receptor, metabotropic 1; targeted mutation 1, Francis Crepel
MGI ID: MGI:1857986
Synonyms: mGlu1-, mGluR1-, mGluR1lacz
Gene: Grm1  Location: Chr10:10561803-10958100 bp, - strand  Genetic Position: Chr10, 3.44 cM, cytoband A2
Alliance: Grm1tm1Crpl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21644
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ neomycin cassette disrupted the exon encoding the seven-transmembrane-helix domain. Immunoblots of membrane preparations of cerebella from homozygous mutant mice showed no detectable native protein using antibodies against the C-terminal and N-terminal parts of the protein. (J:21644)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm1 Mutation:  78 strains or lines available
References
Original:  J:21644 Conquet F, et al., Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1 [see comments]. Nature. 1994 Nov 17;372(6503):237-43
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory