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Targeted Allele Detail
Symbol: Thbdtm1Rdr
Name: thrombomodulin; targeted mutation 1, Robert D Rosenberg
MGI ID: MGI:1857983
Synonyms: TM -
Gene: Thbd  Location: Chr2:148404466-148408188 bp, - strand  Genetic Position: Chr2, 73.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:22630
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced all of the coding sequences of the gene. Transcript and protein levels were found to be reduced by approximately half in heterozygous mutant mice by RNAse protection and Western blot analysis. (J:22630, J:29018, J:42307)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:  7 strains or lines available
Original:  J:22630 Healy AM, et al., Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):850-4
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory