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Thbdtm1Rdr
Targeted Allele Detail
Summary
Symbol: Thbdtm1Rdr
Name: thrombomodulin; targeted mutation 1, Robert D Rosenberg
MGI ID: MGI:1857983
Synonyms: TM -
Gene: Thbd  Location: Chr2:148246391-148250108 bp, - strand  Genetic Position: Chr2, 73.45 cM
Alliance: Thbdtm1Rdr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22630
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced all of the coding sequences of the gene. Transcript and protein levels were found to be reduced by approximately half in heterozygous mutant mice by RNAse protection and Western blot analysis. (J:22630, J:29018, J:42307)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:  23 strains or lines available
References
Original:  J:22630 Healy AM, et al., Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):850-4
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory