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Targeted Allele Detail
Symbol: Cd14tm1Smg
Name: CD14 antigen; targeted mutation 1, Sanna M Goyert
MGI ID: MGI:1857977
Synonyms: CD14-
Gene: Cd14  Location: Chr18:36725067-36726798 bp, - strand  Genetic Position: Chr18, 19.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:32729
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 272 bp genomic segment containing exon 1 and part of exon 2, including the initiation codon, was replaced with a neomycin resistance gene. Flow cytometry experiments on peritoneal macrophages derived from homozygous mice confirmed that no stable protein was made from this allele. (J:32729)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd14 Mutation:  18 strains or lines available
Original:  J:32729 Haziot A, et al., Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 1996 Apr;4(4):407-14
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory