About   Help   FAQ
Apctm1Mmt
Targeted Allele Detail
Summary
Symbol: Apctm1Mmt
Name: APC, WNT signaling pathway regulator; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:1857957
Synonyms: Apcd716, Apcdelta716, MinApcdelta716
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance: Apctm1Mmt page
Nascent intestinal polyps in Apctm1Mmt/Apc+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25200
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 15 at nucleotide 2150. This mutation is predicted to cause premature truncation of the protein at codon 716. (J:25200)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 4 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Apctm1Mmt
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  154 strains or lines available
References
Original:  J:25200 Oshima M, et al., Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4482-6
All:  53 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory