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Apex1tm1Djc
Targeted Allele Detail
Nomenclature
Symbol: Apex1tm1Djc
Name: apurinic/apyrimidinic endonuclease 1; targeted mutation 1, David J Chen
MGI ID: MGI:1857955
Synonyms: Ape/Ref-
Gene: Apex1  Location: Chr14:50924968-50927139 bp, + strand  Genetic Position: Chr14, 26.3 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50702
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 2, intron 2, exon 3 and part of intron 3 were replaced by a neomycin resistance cassette. (J:50702)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apex1 Mutation:  15 strains or lines available
Notes
Homozygous mutant embryos proceed to embryonic day 6.5 - 7 with normal morphology and can be genotyped by PCR from day 9.5 embryo stages before their lethality. Pre-implantation blastocysts are gamma ionizing radiation sensitive (J:50702).
References
Original:  J:50702 Ludwig DL, et al., A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity. Mutat Res. 1998 Oct 21;409(1):17-29
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory