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Targeted Allele Detail
Symbol: Bmp8btm1Blh
Name: bone morphogenetic protein 8b; targeted mutation 1, Brigid L Hogan
MGI ID: MGI:1857954
Gene: Bmp8b  Location: Chr4:123104308-123126094 bp, + strand  Genetic Position: Chr4, 57.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:34057
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 7 kb genomic fragment containing exon 4 was replaced with a neomycin selection cassette. The deleted sequences encode the conserved dibasic proteolytic cleavage site between the pro- and mature regions of the encoded protein. In situ hybridization experiments on sections of testis of homozygous male mice confirmed that no detectable transcript was produced from this allele. (J:34057)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp8b Mutation:  20 strains or lines available
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or TL1 (129S6/SvEvTac).
Original:  J:34057 Zhao GQ, et al., The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 1996 Jul 1;10(13):1657-69
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory