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Tcirg1tm1Ypl
Targeted Allele Detail
Nomenclature
Symbol: Tcirg1tm1Ypl
Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Yi Ping Li
MGI ID: MGI:1857950
Synonyms: Atp6i-
Gene: Tcirg1  Location: Chr19:3896050-3907133 bp, - strand  Genetic Position: Chr19, 3.62 cM
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba and Tcirg1tm1Ypl/Tcirg1tm1Ypl mice show osteopetrorickets

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58795
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A PGK-neomycin resistance cassette replaced 3.0kb of sequence including exons 2-5. (J:58795)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcirg1 Mutation:  17 strains or lines available
References
Original:  J:58795 Li YP, et al., Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 1999 Dec;23(4):447-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory