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Mgmttm1Mse
Targeted Allele Detail
Nomenclature
Symbol: Mgmttm1Mse
Name: O-6-methylguanine-DNA methyltransferase; targeted mutation 1, Mutsuo Sekiguchi
MGI ID: MGI:1857949
Synonyms: Mgmt-
Gene: Mgmt  Location: Chr7:136894463-137128193 bp, + strand  Genetic Position: Chr7, 82.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33696
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of part of the second exon, encoding the initiation codon, with a neomycin cassette. (J:33696)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgmt Mutation:  17 strains or lines available
References
Original:  J:33696 Tsuzuki T, et al., Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent. Carcinogenesis. 1996 Jun;17(6):1215-20
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory