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Targeted Allele Detail
Symbol: Pms2tm1Lisk
Name: PMS1 homolog2, mismatch repair system component; targeted mutation 1, Michael Liskay
MGI ID: MGI:1857947
Synonyms: Pms2-
Gene: Pms2  Location: Chr5:143909964-143933968 bp, + strand  Genetic Position: Chr5, 82.82 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:27389
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette was inserted into exon 2, replacing a highly conserved region of the gene. Protein was not detectable by Western analysis in fibroblast cultures from homozygous mutant animals. (J:27389)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pms2 Mutation:  32 strains or lines available
Original:  J:27389 Baker SM, et al., Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 1995 Jul 28;82(2):309-19
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory