About   Help   FAQ
Targeted Allele Detail
Symbol: Xpatm1Hvs
Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg
MGI ID: MGI:1857939
Synonyms: XPA-, XpaKO
Gene: Xpa  Location: Chr4:46155347-46196311 bp, - strand  Genetic Position: Chr4, 24.49 cM, cytoband C2
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Hvs/Xpatm1Hvs mice display postnatal growth retardation

Show the 10 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:28710
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced exons 3 and 4 of the Xpa gene. No stable intact or truncated XPA transcripts were detected in livers of homozygous mutant animals. (J:28710)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Xpa Mutation:  15 strains or lines available
Original:  J:28710 de Vries A, et al., Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature. 1995 Sep 14;377(6545):169-73
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory