Tsc2^tm1Djk
Targeted Allele Detail

Summary

• Symbol: Tsc2^tm1Djk
• Name: TSC complex subunit 2; targeted mutation 1, David J Kwiatkowski
• MGI ID: MGI:1857938
• Synonyms: Tsc^-, Tsc2^-
• Gene: Tsc2 Location: Chr17:24814790-24851604 bp, - strand Genetic Position: Chr17, 12.41 cM
• Alliance: Tsc2^tm1Djk page

Small size and liver hypoplasia in Tsc2^tm1Djk/Tsc2^tm1Djk embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57631
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into the second coding exon of the gene. (J:57631)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tsc2^tm1Djk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tsc2 Mutation: 77 strains or lines available

References

• Original: J:57631 Onda H, et al., Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest. 1999 Sep;104(6):687-95
• All: 75 reference(s)