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Tsc2tm1Djk
Targeted Allele Detail
Nomenclature
Symbol: Tsc2tm1Djk
Name: TSC complex subunit 2; targeted mutation 1, David J Kwiatkowski
MGI ID: MGI:1857938
Synonyms: Tsc-, Tsc2-
Gene: Tsc2  Location: Chr17:24595816-24632630 bp, - strand  Genetic Position: Chr17, 12.41 cM
Small size and liver hypoplasia in Tsc2tm1Djk/Tsc2tm1Djk embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57631
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin cassette was inserted into the second coding exon of the gene. (J:57631)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tsc2 Mutation:  43 strains or lines available
References
Original:  J:57631 Onda H, et al., Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest. 1999 Sep;104(6):687-95
All:  61 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory