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Mmp7tm1Lmm
Targeted Allele Detail
Nomenclature
Symbol: Mmp7tm1Lmm
Name: matrix metallopeptidase 7; targeted mutation 1, Lynn M Matrisian
MGI ID: MGI:1857932
Synonyms: MAT-, mmp-7-, mmp7-, MMP7-, Mmp7tm1vu
Gene: Mmp7  Location: Chr9:7692090-7699585 bp, + strand  Genetic Position: Chr9, 2.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38609
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced approximately 95 nucleotides of coding sequence in exon 4 of the gene. No transcript for the targeted gene was detectable by Northern blot analysis of RNA from the small intestine of homozygous mutant mice. (J:38609)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp7 Mutation:  1 strain or line available
References
Original:  J:38609 Wilson CL, et al., Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1402-7
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory