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Terctm1Rdp
Targeted Allele Detail
Summary
Symbol: Terctm1Rdp
Name: telomerase RNA component; targeted mutation 1, Ronald DePinho
MGI ID: MGI:1857930
Synonyms: mTerc-, mTR-, Terc-, TR-
Gene: Terc  Location: Chr3:96321753-96322149 bp, - strand  Genetic Position: Chr3, 41.82 cM, cytoband F/G
Alliance: Terctm1Rdp page
Axial/lateral elements of synaptonemal complexes and apoptosis of seminiferous tubules in Terctm1Rdp/Terctm1Rdp mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43517
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of the entire gene with a neomycin cassette. (J:43517)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Terctm1Rdp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Terc Mutation:  8 strains or lines available
References
Original:  J:43517 Blasco MA, et al., Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997 Oct 3;91(1):25-34
All:  186 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory