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Terctm1Rdp
Targeted Allele Detail
Nomenclature
Symbol: Terctm1Rdp
Name: telomerase RNA component; targeted mutation 1, Ronald DePinho
MGI ID: MGI:1857930
Synonyms: mTerc-, mTR-, Terc-, TR-
Gene: Terc  Location: Chr3:96414437-96414833 bp, - strand  Genetic Position: Chr3, 41.82 cM, cytoband F/G
Axial/lateral elements of synaptonemal complexes and apoptosis of seminiferous tubules in Terctm1Rdp/Terctm1Rdp mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43517
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of the entire gene with a neomycin cassette. (J:43517)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Terc Mutation:  5 strains or lines available
References
Original:  J:43517 Blasco MA, et al., Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [see comments]. Cell. 1997 Oct 3;91(1):25-34
All:  168 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory