Mst1r^Fv2-s
Spontaneous Allele Detail

Summary

• Symbol: Mst1r^Fv2-s
• Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Friend virus susceptibility 2
• MGI ID: MGI:1857882
• Synonyms: Fv2^ss
• Gene: Mst1r Location: Chr9:107784072-107797582 bp, + strand Genetic Position: Chr9, 59.07 cM, cytoband F1
• Alliance: Mst1r^Fv2-s page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This allele expresses both a normal transcript and a mutant transcript initiating in intron 10 that encodes a truncated form of the receptor that lacks most of the extracellular domain. (J:57881)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mst1r Mutation: 59 strains or lines available

Notes

This virus susceptibility allele is found in strains NIH Swiss, DDD, BALB/c, DBA, AKR, and others. Mouse strains carrying this allele are susceptible to progression of infection by Friend virus. To date the resistance (wild-type) allele has been found only in strains A, C57BL/6 and other members of the C57 and C58 family and in M. spretus. This locus probably also influences susceptibility to Rauscher leukemia virus, and the locus named Rv2 may be the identical.

References

• Original: J:172785 Friend C, Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med. 1957 Apr 1;105(4):307-18
• All: 7 reference(s)