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Targeted Allele Detail
Symbol: Atp2b2tm1Ges
Name: ATPase, Ca++ transporting, plasma membrane 2; targeted mutation 1, Gary E Shull
MGI ID: MGI:1857876
Synonyms: Pmca2 -
Gene: Atp2b2  Location: Chr6:113720792-114019574 bp, - strand  Genetic Position: Chr6, 52.85 cM
Atp2b2tm1Ges/Atp2b2tm1Ges mice exhibit an unsteady gait and difficulty in maintaining balance

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:48863
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 19, which encodes transmembrane domains essential for transport activity. Northern blot analysis demonstrated that no detectable transcript was produced from this allele in brain of homozygous mice. (J:48863)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Atp2b2 Mutation:  53 strains or lines available
Original:  J:48863 Kozel PJ, et al., Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem. 1998 Jul 24;273(30):18693-6
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory