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Drd2tm1Low
Targeted Allele Detail
Nomenclature
Symbol: Drd2tm1Low
Name: dopamine receptor D2; targeted mutation 1, Malcolm J Low
MGI ID: MGI:1857875
Synonyms: D2-, D2KO, D2 KO, D2R-, Drd2-
Gene: Drd2  Location: Chr9:49340662-49407214 bp, + strand  Genetic Position: Chr9, 26.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41858
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exon 7 and part of exon 8 was replaced by a neomycin resistance cassette. (J:41858)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  31 strains or lines available
Notes
Unlike mice homozygous for Drd2tm1Ebo mice do not display Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:47001)

References
Original:  J:41858 Kelly MA, et al., Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron. 1997 Jul;19(1):103-13
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory