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Sod1tm1Leb
Targeted Allele Detail
Nomenclature
Symbol: Sod1tm1Leb
Name: superoxide dismutase 1, soluble; targeted mutation 1, Russell M Lebovitz
MGI ID: MGI:1857873
Synonyms: Cu,Zn-SOD-, CuZnSOD-, SOD1-, SOD1m1BCM
Gene: Sod1  Location: Chr16:90220762-90226333 bp, + strand  Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64299
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exons 1 and 2 with a PGK-hprt expression cassette. Protein was not detected in brain of homozygous mutant mice. (J:64299)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sod1 Mutation:  15 strains or lines available
References
Original:  J:64299 Matzuk MM, et al., Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology. 1998 Sep;139(9):4008-11
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory