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Sod1tm1Cep
Targeted Allele Detail
Nomenclature
Symbol: Sod1tm1Cep
Name: superoxide dismutase 1, soluble; targeted mutation 1, Cephalon, Inc.
MGI ID: MGI:1857872
Synonyms: SOD1-
Gene: Sod1  Location: Chr16:90220742-90226322 bp, + strand  Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33472
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the entire coding region and sequences immediately 5' of exon 1. Immunoblot and enzyme activity analyses did not detect protein in red blood cells from homozygous mutant mice. (J:33472)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod1 Mutation:  24 strains or lines available
References
Original:  J:33472 Reaume AG, et al., Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet. 1996 May;13(1):43-7
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory