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Targeted Allele Detail
Symbol: Hoxb1tm3Mrc
Name: homeobox B1; targeted mutation 3, Mario R Capecchi
MGI ID: MGI:1857859
Synonyms: Hoxb1BloxP
Gene: Hoxb1  Location: Chr11:96365752-96368256 bp, + strand  Genetic Position: Chr11, 59.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:41540
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of a 371 bp BglII fragment of exon 2 with a loxP-flanked neomycin cassette and an insertion of a 12 bp linker into exon 1. The neomycin cassette was removed via Cre-mediated recombination in the final allele. (J:41540)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 74 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb1 Mutation:  9 strains or lines available
Original:  J:41540 Rossel M, et al., Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development. 1999 Nov;126(22):5027-40
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory