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Hoxdtm3Ddu
Targeted Allele Detail
Nomenclature
Symbol: Hoxdtm3Ddu
Name: homeobox D cluster; targeted mutation 3, Denis Duboule
MGI ID: MGI:1857854
Synonyms: Hoxd12tm1Ddu, HoxDRXI, L2
Gene: Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47900
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Deletion
 
Mutation detailsA neomycin resistance cassette flanked by loxP sites replaced the regulatory element, RXI, located in the intergenic region between Hoxd12 and Hoxd13. This selection cassette was excised by breeding mice carrying this mutation with a Cre deleter strain. (J:47900)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:  0 strains or lines available
References
Original:  J:47900 Herault Y, et al., Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex. Development. 1998 May;125(9):1669-77
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory