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Rarbtm1Mma
Targeted Allele Detail
Nomenclature
Symbol: Rarbtm1Mma
Name: retinoic acid receptor, beta; targeted mutation 1, Manuel Mark
MGI ID: MGI:1857851
Synonyms: RARbeta-
Gene: Rarb  Location: Chr14:16430839-16819156 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43344
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced exon 9 and a 5' region of exon 10, both of which encode a portion of the functionally essential ligand-binding domain common to all isoforms. Western blot analysis demonstrated an absence of functional protein in homozygous mutant embryos. RNAse protection assays of mRNA derived from homozygous mutant embryos showed that only truncated transcripts were present. (J:43344)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 78 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  25 strains or lines available
References
Original:  J:43344 Ghyselinck NB, et al., Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997 Jun;41(3):425-47
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory