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Targeted Allele Detail
Symbol: Dlx2tm1Jlr
Name: distal-less homeobox 2; targeted mutation 1, John L Rubenstein
MGI ID: MGI:1857828
Synonyms: Dlx-2-, Dlx-2-D5/neo
Gene: Dlx2  Location: Chr2:71543408-71546754 bp, - strand  Genetic Position: Chr2, 42.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:29443
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced part of exon 1 and all of exons 2 and 3. Northern analysis of poly(A)+ RNA using a probe that corresponds to exon 3 did not detect transcript in homozygous mutant whole E14.5 embryo. In situ RNA hybridization did not detect gene expression in the gut of E14.5 homozygous mutant embryos. (J:29443)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 78 assay results
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dlx2 Mutation:  3 strains or lines available
Original:  J:29443 Qiu M, et al., Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 1995 Oct 15;9(20):2523-38
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory