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Targeted Allele Detail
Symbol: Rxrbtm1Ipc
Name: retinoid X receptor beta; targeted mutation 1, Pierre Chambon
MGI ID: MGI:1857822
Synonyms: Rarbeta-, RXRbeta-, Xbeta
Gene: Rxrb  Location: Chr17:34031812-34038393 bp, + strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:30560
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGenomic sequences encoding the DNA-binding domain in exons 3 and 4 were replaced by a neomycin cassette. RT-PCR analysis on total RNA derived from several tissues of homozygous mice revealed that transcripts corresponding to exon 2 as well as exons 5-9 were present at low levels in homozygous mice. The authors do not rule out the possiblility that some mutant protein could be expressed in homozygotes. (J:30560)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxrb Mutation:  9 strains or lines available
Original:  J:30560 Kastner P, et al., Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 1996 Jan 1;10(1):80-92
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory