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Transgenic Allele Detail
Symbol: EdarTg(OVE1B)Ove
Name: ectodysplasin-A receptor; transgene insertion OVE1B, Paul Overbeek
MGI ID: MGI:1857813
Synonyms: EdarTgN(OVE1B)Ove, OVE 1B
Gene: Edar  Location: Chr10:58600789-58675654 bp, - strand  Genetic Position: Chr10, 29.37 cM, cytoband B3
Strain of Origin:  (C57BL/6 x C3H)F2
Transgene Type:    Transgenic
Mutations:    Deletion, Insertion, Inversion
Mutation detailsA transgene containing a hybrid DNA construct, which includes the regulatory sequences of the mouse alpha-crystallin gene and the early region of SV40, inserted into the gene. A founder mouse from one microinjection event produced offspring carrying two different integration sites. The subsequent lines were called EdarTgN(OVE1A)Ove and EdarTgN(OVE1B)Ove. In both cases, integration was accompanied by a genomic deletion and an intrachromosomal inversion. The deletions were found to be overlapping. This allele is defined by a noncomplementation test with Edardl, and contains a 600 kb deletion. (J:10318, J:50575, J:56496)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edar Mutation:  21 strains or lines available

Phenotypic Similarity to Human Syndrome: hypohidrotic/anhidrotic ectodermal dysplasia (OMIM 305100, 224900, and 129490). Similar phenotypes have also been described in mice for the Tabby allelic series at the Eda locus.

Original:  J:10318 Shawlot W, et al., Insertional inactivation of the downless gene in a family of transgenic mice. Mol Biol Med. 1989 Aug;6(4):299-307
All:  4 reference(s)

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last database update
MGI 6.03
The Jackson Laboratory