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Aqp4tm1Ask
Targeted Allele Detail
Nomenclature
Symbol: Aqp4tm1Ask
Name: aquaporin 4; targeted mutation 1, Alan S Verkman
MGI ID: MGI:1857808
Synonyms: AQP4-
Gene: Aqp4  Location: Chr18:15389394-15403684 bp, - strand  Genetic Position: Chr18, 8.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42704
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of the exon 1 coding sequence (bp 298 - 381) into ~1kb of intron 1. Northern blots of brain homogenates from homozygous mutant mice showed minimally detectable truncated Aqp4 transcripts. Western blots of brain homogenates from homozygous mutant mice showed no detectable Aqp4 protein. Immunocytochemistry of renal tissue from homozygous mutant mice showed no detectable Aqp4 protein. (J:42704)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp4 Mutation:  17 strains or lines available
References
Original:  J:42704 Ma T, et al., Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1;100(5):957-62
All:  74 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory