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Targeted Allele Detail
Symbol: Aqp1tm1Ask
Name: aquaporin 1; targeted mutation 1, Alan S Verkman
MGI ID: MGI:1857807
Synonyms: AQP1-
Gene: Aqp1  Location: Chr6:55336432-55348555 bp, + strand  Genetic Position: Chr6, 27.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:45888
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.8 kb neomycin cassette replaced part of the exon 1 coding sequence and ~1.3 kb of intron 1. Northern blot analysis of kidney, lung, eye, spleen, and heart homogenates from homozygous mutant mice did not detect full-length transcripts. Western blots of kidney, lung, eye, spleen, and heart homogenates from homozygous mutant mice did not detect showed no detectable encoded protein. (J:45888)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp1 Mutation:  13 strains or lines available
Original:  J:45888 Ma T, et al., Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998 Feb 20;273(8):4296-9
All:  70 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory