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Targeted Allele Detail
Symbol: Zeb1tm2Yhi
Name: zinc finger E-box binding homeobox 1; targeted mutation 2, Yujiro Higashi
MGI ID: MGI:1857799
Synonyms: deltaEF1-, deltaEF1null(lacZ), Tcf8-, Zeb1tm2Yhi, Zfhx1a-
Gene: Zeb1  Location: Chr18:5591860-5775467 bp, + strand  Genetic Position: Chr18, 4.42 cM
Inner ear abnormality in Zeb1tm2Yhi/Zeb1tm2Yhi and Zeb1tm2Yhi/Zeb1Tw mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:45575
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ-neo cassette including termination signals replaced exon 1. The targeted allele encodes a fusion protein that lacks the DNA-binding and homeodomains functionally essential to the endogenous protein. Northern blot analysis showed an absence of normal transcript in homozygous mutant embryos. The expression pattern of beta-galactosidase largely resembled that of the endogenous gene, with the noted exception of expression in the notochord. (J:45575)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 316 assay results
In Structures Affected by this Mutation: 45 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zeb1 Mutation:  15 strains or lines available
Original:  J:45575 Takagi T, et al., DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development. 1998 Jan;125(1):21-31
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory