Itga6tm1Egl
Targeted Allele Detail
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Symbol: |
Itga6tm1Egl |
Name: |
integrin alpha 6; targeted mutation 1, Elisabeth Georges-Labouesse |
MGI ID: |
MGI:1857793 |
Synonyms: |
alpha6-, Itga6tmZP149 |
Gene: |
Itga6 Location: Chr2:71617236-71688761 bp, + strand Genetic Position: Chr2, 42.79 cM
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Alliance: |
Itga6tm1Egl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:33712
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Parent Cell Line: |
H1 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin cassette replaced a genomic fragment that contains three coding exons of the gene corresponding to amino acids 62-194. Northern analysis of total RNA extracted from homozygous tissue showed the absence of full length message, and a presence of a truncated mRNA that should not yield a functional protein. Immunohistochemical analysis did not detect any protein produced from this allele in tissue sections derived from from homozygous embryos.
(J:33712)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Itga6 Mutation: |
209 strains or lines available
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Original: |
J:33712 Georges-Labouesse E, et al., Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet. 1996 Jul;13(3):370-3 |
All: |
14 reference(s) |
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