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Itga6tm1Egl
Targeted Allele Detail
Nomenclature
Symbol: Itga6tm1Egl
Name: integrin alpha 6; targeted mutation 1, Elisabeth Georges-Labouesse
MGI ID: MGI:1857793
Synonyms: alpha6-, Itga6tmZP149
Gene: Itga6  Location: Chr2:71745616-71858416 bp, + strand  Genetic Position: Chr2, 42.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33712
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced a genomic fragment that contains three coding exons of the gene corresponding to amino acids 62-194. Northern analysis of total RNA extracted from homozygous tissue showed the absence of full length message, and a presence of a truncated mRNA that should not yield a functional protein. Immunohistochemical analysis did not detect any protein produced from this allele in tissue sections derived from from homozygous embryos. (J:33712)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga6 Mutation:  129 strains or lines available
References
Original:  J:33712 Georges-Labouesse E, et al., Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet. 1996 Jul;13(3):370-3
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory