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Targeted Allele Detail
Symbol: Ikbkbtm1Mka
Name: inhibitor of kappaB kinase beta; targeted mutation 1, Michael Karin
MGI ID: MGI:1857769
Synonyms: IKKbeta-
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Anemic appearance of E13.5 Ikbkbtm1Mka/Ikbkbtm1Mka mutants

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:55737
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced part of the second and the entire third coding exon of the gene, which encodes for a part of the kinase domain of the protein. Western blots of protein extracts from embryonic fibroblasts from homozygous mutant mice showed no detectable protein for the targeted gene. (J:55737)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  9 strains or lines available
ES cell line = GS (Genome Systems).
Original:  J:55737 Li ZW, et al., The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999 Jun 7;189(11):1839-45
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory