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Targeted Allele Detail
Symbol: Parp1tm1Hsmm
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1, Hiroshi Suzuki Mitsuko Masutani
MGI ID: MGI:1857765
Synonyms: Parp-
Gene: Parp1  Location: Chr1:180568924-180601254 bp, + strand  Genetic Position: Chr1, 84.44 cM, cytoband H5
Germline Transmission:  Earliest citation of germline transmission: J:53360
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 1, 10 bp downstream of the ATG codon. Protein activity was not detected in tissues derived from homozygous mice. Western blot analysis detected a 113 kDa protein in homozygous mice, but this truncated form is predicted to be inactive beacuse it should lack a critical N-terminal zinc finger. (J:53360)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Parp1 Mutation:  46 strains or lines available
Null mice appear healthy and fertile with no gross abnormalities. No skin hyperplasia or obesity was observed. These mice were used to examine the role of ADPRP in Streptozotocin induced diabetes. STZ injection caused a significant increase in blood glucose concentrations of wildtype mice as well as necrosis in islet cells leading to an eventual loss on beta cells. In contrast, homozygous mice are protected from STZ-induced diabetes. Glucose levels in these animals remained relatively normal and islet beta cell death was markedly less in these animals (J:53360).
Original:  J:53360 Masutani M, et al., Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2301-4
All:  13 reference(s)

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