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Parp1tm1Hsmm
Targeted Allele Detail
Nomenclature
Symbol: Parp1tm1Hsmm
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1, Hiroshi Suzuki Mitsuko Masutani
MGI ID: MGI:1857765
Synonyms: Parp-
Gene: Parp1  Location: Chr1:180568975-180601254 bp, + strand  Genetic Position: Chr1, 84.44 cM, cytoband H5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53360
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Parp1 Mutation:  27 strains or lines available
Notes
Null mice appear healthy and fertile with no gross abnormalities. No skin hyperplasia or obesity was observed. These mice were used to examine the role of ADPRP in Streptozotocin induced diabetes. STZ injection caused a significant increase in blood glucose concentrations of wildtype mice as well as necrosis in islet cells leading to an eventual loss on beta cells. In contrast, homozygous mice are protected from STZ-induced diabetes. Glucose levels in these animals remained relatively normal and islet beta cell death was markedly less in these animals (J:53360).

References
Original:  J:53360 Masutani M, et al., Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2301-4
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory