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Adam2tm1Dgm
Targeted Allele Detail
Nomenclature
Symbol: Adam2tm1Dgm
Name: a disintegrin and metallopeptidase domain 2; targeted mutation 1, Diana G Myles
MGI ID: MGI:1857764
Synonyms: fertilin beta-
Gene: Adam2  Location: Chr14:66264778-66315182 bp, - strand  Genetic Position: Chr14, 34.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50040
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 14, encoding the predicted disintegrin domain active site. Western blot analysis did not detect the encoded protein in spermatogenic cells and sperm derived from homozygous mice. (J:50040)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam2 Mutation:  30 strains or lines available
References
Original:  J:50040 Cho C, et al., Fertilization defects in sperm from mice lacking fertilin beta. Science. 1998 Sep 18;281(5384):1857-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory