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Spontaneous Allele Detail
Symbol: Slc11a1s
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; pathogen susceptibility (Bcg/Ity/Lsh)
MGI ID: MGI:1857755
Synonyms: Bcgs, Itys, Lshs, Nramp1-, Nramp1Asp169, Nramp1D169
Gene: Slc11a1  Location: Chr1:74375195-74386062 bp, + strand  Genetic Position: Chr1, 38.54 cM
Strain of Origin:  multiple strains
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsThis allele is associated with susceptibility to infection with diverse pathogens, including several Mycobacterium species, Salmonella typhimurium, and Leishmania donovani. In this allele a G to A transition results in a non-conservative replacement of Gly to Asp at position 105 within the second predicted transmembrane domain of the protein. The protein carries another non-conservative replacement of Gly to Asp at position 169 within the fourth predicted transmembrane domain. (J:4762, J:20139, J:35004)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc11a1 Mutation:  11 strains or lines available
Cation concentrations would be elevated in macrophages from mice carrying mutations that alter Slc11a1 transport function, i.e. the Slc11a1s allele, rendering susceptibility to infection (J:50686). This model is supported by the observation that mice normally resistant to Mycobacterium avium infection loose their advantage over Slc11a1s mice when exposed to an excess of iron (J:50686). Strains carrying this allele include BALB/cJ, C57BL/6J, C57BL/10J, DBA/1J, SWV, NZW/LacJ, MOLF/Ei.

Original:  J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
All:  53 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory