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Adam17tm1Imx
Targeted Allele Detail
Nomenclature
Symbol: Adam17tm1Imx
Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Immunex
MGI ID: MGI:1857753
Synonyms: ADAM17deltaZn, ADAM17Zndelta, TACE-, tacedeltaZn
Gene: Adam17  Location: Chr12:21323509-21373632 bp, - strand  Genetic Position: Chr12, 8.3 cM
Adam17tm1Imx/Adam17tm1Imx embryos develop internal hemorrhage

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38527
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin cassette replaced a 1.2kb fragment of the gene, which encodes the zinc-binding domain. (J:38527)
Phenotypes
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Expression
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:  9 strains or lines available
References
Original:  J:38527 Black RA, et al., A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997 Feb 20;385(6618):729-33
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory