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Targeted Allele Detail
Symbol: Nr3c1tm1Gsc
Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, Gunther Schutz
MGI ID: MGI:1857745
Synonyms: GR-, GRhypo
Gene: Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:27441
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into exon 2. This allele is a hypomorphic allele; an mRNA containing an ORF encoding an amino-terminal truncated protein with intact DNA and ligand-binding domains is generated. (J:27441)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 40 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:  28 strains or lines available
Original:  J:27441 Cole TJ, et al., Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 1995 Jul 1;9(13):1608-21
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory