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Targeted Allele Detail
Symbol: Foxc2tm1Miu
Name: forkhead box C2; targeted mutation 1, Naoyuki Miura
MGI ID: MGI:1857740
Synonyms: Mfh1-, MFH-1-
Gene: Foxc2  Location: Chr8:121116171-121118895 bp, + strand  Genetic Position: Chr8, 70.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:55316
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the entire coding region of the gene. RT-PCR analysis on RNA derived from E11.5 homozygous embryos confirmed that no detectable transcript was produced from this allele. (J:55316)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 45 assay results
In Structures Affected by this Mutation: 32 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxc2 Mutation:  9 strains or lines available
Original:  J:55316 Iida K, et al., Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development. 1997 Nov;124(22):4627-38
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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