Blm^tm1Ches
Targeted Allele Detail

Summary

• Symbol: Blm^tm1Ches
• Name: Bloom syndrome, RecQ like helicase; targeted mutation 1, Nicholas Chester
• MGI ID: MGI:1857708
• Synonyms: Blm-, Blm^neo
• Gene: Blm Location: Chr7:80104741-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Blm^tm1Ches page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50843
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 180 bp of exon 8. Faint transcripts of altered mobility were detected in Northern blot analysis on RNA derived from embryonic fibroblasts of homozygous mice. (J:50843, J:112115)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Blm^tm1Ches

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Blm Mutation: 87 strains or lines available

References

• Original: J:50843 Chester N, et al., Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev. 1998 Nov 1;12(21):3382-93
• All: 8 reference(s)