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Vhltm1Wml
Targeted Allele Detail
Nomenclature
Symbol: Vhltm1Wml
Name: von Hippel-Lindau tumor suppressor; targeted mutation 1, W Marston Linehan
MGI ID: MGI:1857702
Synonyms: VHL -
Gene: Vhl  Location: Chr6:113623959-113631633 bp, + strand  Genetic Position: Chr6, 52.81 cM
Placental histopathology of normal and Vhltm1Wml/Vhltm1Wml embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42486
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing part of exon 1, exon 2 and part of exon 3 was replaced by a neomycin expression cassette. (J:42486)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vhl Mutation:  6 strains or lines available
References
Original:  J:42486 Gnarra JR, et al., Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory