Vhl^tm1Wml
Targeted Allele Detail

Summary

• Symbol: Vhl^tm1Wml
• Name: von Hippel-Lindau tumor suppressor; targeted mutation 1, W Marston Linehan
• MGI ID: MGI:1857702
• Synonyms: VHL -
• Gene: Vhl Location: Chr6:113600955-113608595 bp, + strand Genetic Position: Chr6, 52.81 cM
• Alliance: Vhl^tm1Wml page

Placental histopathology of normal and Vhl^tm1Wml/Vhl^tm1Wml embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42486
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 1, exon 2 and part of exon 3 was replaced by a neomycin expression cassette. (J:42486)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Vhl^tm1Wml

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vhl Mutation: 16 strains or lines available

References

• Original: J:42486 Gnarra JR, et al., Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7
• All: 5 reference(s)