About   Help   FAQ
Targeted Allele Detail
Symbol: Smad5tm1Cxd
Name: SMAD family member 5; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1857699
Synonyms: Smad5ex6/ex6
Gene: Smad5  Location: Chr13:56703010-56742377 bp, + strand  Genetic Position: Chr13, 30.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:53289
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 6 of the gene, causing truncation of the protein 179 amino acids from the C-terminal end. Northern analysis of RNA isolated from mutant embryos failed to show any transcript for the targeted gene. (J:53289)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad5 Mutation:  2 strains or lines available
Original:  J:53289 Yang X, et al., Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory