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Smad5tm1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Smad5tm1Cxd
Name: SMAD family member 5; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1857699
Synonyms: Smad5ex6/ex6
Gene: Smad5  Location: Chr13:56703010-56742377 bp, + strand  Genetic Position: Chr13, 30.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53289
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 6 of the gene, causing truncation of the protein 179 amino acids from the C-terminal end. Northern analysis of RNA isolated from mutant embryos failed to show any transcript for the targeted gene. (J:53289)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad5 Mutation:  6 strains or lines available
References
Original:  J:53289 Yang X, et al., Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory