Lats1^tm1Tx
Targeted Allele Detail

Summary

• Symbol: Lats1^tm1Tx
• Name: large tumor suppressor; targeted mutation 1, Tian Xu
• MGI ID: MGI:1857685
• Synonyms: Lats1^-
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^tm1Tx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52536
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequence encoding amino acids 756 - 1130 of the protein. Immunoprecipitation and Western blots of embryonic fibroblasts lysates from homozygous mutant mice showed no detectable protein for the targeted gene. (J:52536)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lats1^tm1Tx

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 48 strains or lines available

References

• Original: J:52536 St. John MA, et al., Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999 Feb;21(2):182-6
• All: 5 reference(s)