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Rxratm1Rev
Targeted Allele Detail
Nomenclature
Symbol: Rxratm1Rev
Name: retinoid X receptor alpha; targeted mutation 1, Ronald M Evans
MGI ID: MGI:1857672
Synonyms: RXRalpha-
Gene: Rxra  Location: Chr2:27566452-27652969 bp, + strand  Genetic Position: Chr2, 19.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18047
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing part of exon 3 and intron 3 was replaced with a neomycin resistance cassette. RT-PCR analysis on RNA derived from E13.5 embryos indicated that no normal transcript was produced from this allele in homozygous embryos. (J:18047)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 144 assay results
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:  24 strains or lines available
References
Original:  J:18047 Sucov HM, et al., RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 1994 May 1;8(9):1007-18
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory