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Targeted Allele Detail
Symbol: Prrx2tm1Hubr
Name: paired related homeobox 2; targeted mutation 1, Hubrecht Institute
MGI ID: MGI:1857641
Synonyms: Prx2 -
Gene: Prrx2  Location: Chr2:30845064-30881251 bp, + strand  Genetic Position: Chr2, 21.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:50488
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ/PGK-Hygro cassette was inserted just upstream of the homeobox domain, such that the lacZ encoding sequence is in-frame. The allele is expected to express the first 88 amino acids of the Prrx2 protein, fused to the Beta-gal protein, in a pattern identical to that of the Prrx2 gene. The absence of both the homeodomain and the aristaless domain make it unlikely that the protein retains any endogenous biochemical activity. (J:50488)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 50 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prrx2 Mutation:  7 strains or lines available
Original:  J:50488 ten Berge D, et al., Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs. Development. 1998 Oct;125(19):3831-42
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory