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Bmi1tm1Brn
Targeted Allele Detail
Nomenclature
Symbol: Bmi1tm1Brn
Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Anton Berns
MGI ID: MGI:1857632
Synonyms: bmi-1-, Bmi1-
Gene: Bmi1  Location: Chr2:18677018-18686629 bp, + strand  Genetic Position: Chr2, 12.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17712
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequences encoding the ATG start codon, the zinc finger motif, and part of the helix-turn-helix motif were replaced either with a hygromycin-resistance cassette or one that conveyed neomycin-resistance. (J:17712)
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 122 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmi1 Mutation:  15 strains or lines available
References
Original:  J:17712 van der Lugt NM, et al., Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994 Apr 1;8(7):757-69
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory