About   Help   FAQ
Apobtm3Sgy
Targeted Allele Detail
Summary
Symbol: Apobtm3Sgy
Name: apolipoprotein B; targeted mutation 3, Stephen G Young
MGI ID: MGI:1857625
Synonyms: apoB-
Gene: Apob  Location: Chr12:8027648-8066835 bp, + strand  Genetic Position: Chr12, 3.53 cM
Alliance: Apobtm3Sgy page
The yolk sac visceral endoderm from Apobtm3Sgy/Apobtm3Sgy embryos contains foamy vacuoles

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23315
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA sequence-insertion vector was used to interrupt the coding sequence after exon 4 and is predicted to result in a truncated protein produced from this allele. (J:23315)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apob Mutation:  221 strains or lines available
Notes
The presence of Tg(APOB)1102Sgy (J:81265) prevented the lethal developmental abnormalities caused by this allele.
References
Original:  J:23315 Farese RV Jr, et al., Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1774-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory