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Targeted Allele Detail
Symbol: Rarbtm1Ipc
Name: retinoic acid receptor, beta; targeted mutation 1, Pierre Chambon
MGI ID: MGI:1857623
Synonyms: Abeta, Rarb2-, RARbeta2-
Gene: Rarb  Location: Chr14:16430839-16819156 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Germline Transmission:  Earliest citation of germline transmission: J:21486
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsAblation of the expression of the most abundant isoform, Rarbeta2, encoded by this locus was achieved in two steps. First, all of the in-frame start codons for the Rarbeta2 isoform were eliminated by site-specific mutagenesis of nucleotides 459 through 491. Second, a neomycin resistance gene was inserted into the first exon of the Rarbeta2 isoform, exon 4. RT-PCR and Western blot analysis, using isoform specific primers and antibodies, showed a lack of Rarbeta2 mRNA and protein, as well as normal levels of transcript and protein corresponding to the other isoforms. (J:21486)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 66 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  19 strains or lines available
Original:  J:21486 Mendelsohn C, et al., Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal. Dev Biol. 1994 Nov;166(1):246-58
All:  15 reference(s)

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MGI 6.11
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