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Dnmt1tm1Enl
Targeted Allele Detail
Nomenclature
Symbol: Dnmt1tm1Enl
Name: DNA methyltransferase (cytosine-5) 1; targeted mutation 1, En Li
MGI ID: MGI:1857601
Synonyms: DNMT-, Dnmt1s, Dnmts
Gene: Dnmt1  Location: Chr9:20907206-20959888 bp, - strand  Genetic Position: Chr9, 7.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36234
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin cassette into a Sal1 site corresponding to amino acid 310. (J:36234)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  44 strains or lines available
References
Original:  J:36234 Lei H, et al., De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 1996 Oct;122(10):3195-205
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory