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CrygbNop
Spontaneous Allele Detail
Nomenclature
Symbol: CrygbNop
Name: crystallin, gamma B; nuclear opacity
MGI ID: MGI:1857597
Synonyms: Cat2no, CrygbCat2-nop, Nop
Gene: Crygb  Location: Chr1:65080219-65082288 bp, - strand  Genetic Position: Chr1, 32.82 cM
Mutation
origin
Strain of Origin:  (101/El x C3H/El)F1
Mutation
description
Allele Type:    Spontaneous
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Inheritance:    Dominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crygb Mutation:  3 strains or lines available
Notes
Both homozygotes and heterozygotes are fully viable and fertile, and penetrance is complete in both. The nuclear opacity is seen as a white spot in the eye. The cataractous lens shows decreased activity of four glycolytic enzymes, a decreased amount of glutathione disulfide, and loss of a single protein, probably a gamma-crystallin, as revealed by isoelectric focusing (J:7589, J:23992).

References
Original:  J:7589 Graw J, et al., Genetical and biochemical studies of a dominant cataract mutant in mice. Exp Eye Res. 1984 Jul;39(1):37-45
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory