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Ptk2tm1Imeg
Targeted Allele Detail
Nomenclature
Symbol: Ptk2tm1Imeg
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Institute of Molecular Embryology and Genetics
MGI ID: MGI:1857596
Synonyms: FAK-
Gene: Ptk2  Location: Chr15:73205102-73423280 bp, - strand  Genetic Position: Chr15, 33.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29273
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into sequences encoding the beginning of the kinase domain. Western blot analysis of lysates derived from E8.5 embryos demonstrated that the protein was absent in homozygotes. (J:29273)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:  70 strains or lines available
References
Original:  J:29273 Ilic D, et al., Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 1995 Oct 12;377(6549):539-44
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory