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Cryga1Neu
Chemically induced Allele Detail
Nomenclature
Symbol: Cryga1Neu
Name: crystallin, gamma A; 1 Neuherberg
MGI ID: MGI:1857595
Synonyms: ENU-436
Gene: Cryga  Location: Chr1:65100389-65103373 bp, - strand  Genetic Position: Chr1, 32.84 cM
Mutation
origin
Strain of Origin:  (101 x C3H)F1
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA point mutation in exon 2 introduces an A to G transition at position 230 of the encoded cDNA. This mutation is predicted to lead to the amino acid substitution of aspartic acid to glycine at position 77, affecting the connecting peptide between the second and third Greek-key motif. (J:50319)
Inheritance:    Dominant
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryga Mutation:  2 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous mice (J:21950)

References
Original:  J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory